The National Institutes of Health (NIH) developed the NIH Manuscript Submission (NIHMS) system to facilitate the submission of peer-reviewed manuscripts for inclusion in PubMed Central (PMC) in support of the NIH Public Access Policy. Since its inception in 2005, NIHMS has expanded to support the public access policies of other organizations and government agencies (for more details, see the Funders List). The NIHMS system allows users, such as authors, principal investigators, and publishers to supply material for conversion to XML documents in a format that can be ingested by PMC. Depositing a manuscript in NIHMS for inclusion in PMC is a multi-step process, requiring an author to approve the deposited files and associated funding before conversion and the PMC-ready version after conversion.

NIHMS Overview: Step 1. Deposit Files. Step 2. Initial Approval. Step 3. NIHMS Conversion. Step 4. Final Approval. Step 5. PMCID Assigned. Step 6. Available on PMC.

For a more in-depth overview of the NIHMS process, please see What steps are involved in the NIHMS process? Additional information on using the NIHMS system may be found in the NIHMS FAQ, Step-by-Step Tutorials, and Glossary.